Rob Malenka @ Nancy Pritzker Laboratory Department of Psychiatry and Behavioral Sciences, Stanford Medical Center

<BODY BGCOLOR="#FFFFFF" TEXT="#000000" LINK="#0000FF"> <A NAME=home> <br> <A HREF="#home" TARGET="_self">Home</A> | <A HREF="#people" TARGET="_self">People</A> | <A HREF="#contact" TARGET="_self">Contact</A> | <A HREF="#rob_publi" TARGET="_self">Rob Malenka`s Publications</A> | <A HREF="#Login" TARGET="_self">Login</A> <H2>Welcome to Malenka`s lab website</H2> <b>Research Program</b> <br> <br> Long-lasting activity-dependent changes in the efficacy of synaptic transmission play an important role in the development of neural circuits and are thought to mediate many forms of learning and memory. Therefore elucidating the molecular mechanisms by which these changes occur will have profound implications for understanding many important nervous system functions including how future behavior is modified by past experience. Work from my laboratory has demonstrated that there are a variety of related but mechanistically distinct forms of synaptic plasticity. A major goal of my laboratory is to elucidate both the specific molecular events that are responsible for the triggering of these various forms of synaptic plasticity and the exact modifications in synaptic proteins that are responsible for the observed, long-lasting changes in synaptic efficacy. To accomplish this we use cellular electrophysiological recording techniques to examine synaptic plasticity in a variety of different in vitro preparations including thin slices of various regions of the rodent brain and primary neurons in culture. We also use molecular and cell biological techniques to examine the activity-dependent modulation of neurotransmitter receptors and to express dominant negative forms of various synaptic proteins so that their exact functions can be determined. An additional complementary approach has involved examining synaptic physiology and synaptic plasticity in various mutant mouse lines lacking specific synaptic proteins. <br> <br> A related area of research in my laboratory is the elucidation of the synaptic action of drugs of abuse such as the psychostimulants cocaine and amphetamine. Toward this end, we have developed in vitro slice preparations of the nucleus accumbens and ventral tegmental area, brain regions which are thought to mediate several of the behavioral effects of drugs of abuse. We are currently using a variety of electrophysiological and biochemical techniques with the hope of determining how acute and chronic exposure to drugs of abuse modify synaptic and circuit function in these brain areas. It is our belief that the knowledge gained from the work on the molecular mechanisms underlying synaptic plasticity will provide important clues to the molecular mechanisms underlying the development of tolerance, dependence and addiction. <br> <br> <A NAME=people> <br> <A HREF="#home" TARGET="_self">Home</A> | <A HREF="#people" TARGET="_self">People</A> | <A HREF="#contact" TARGET="_self">Contact</A> | <A HREF="#rob_publi" TARGET="_self">Rob Malenka`s Publications</A> | <A HREF="#Login" TARGET="_self">Login</A> <H2>People</H2> E-mail: <a href="mailto:stell@stanford.edu">David Stellwagen</a> <br><b>Postdoc Research Associate</b> <br> <br> E-mail: <a href="mailto:wmorishi@stanford.edu">Wade Morishita</a> <br><b>Postdoc Research Associate</b> <br> <br> E-mail: <a href="mailto:yandong@stanford.edu">Yandi Dong</a> <br><b>Postdoc Research Associate</b> <br> <br> Unavailable: <a href="mailto:">Nicole Calakos</a> <br><b>Postdoc Research Associate</b> <br> <br> E-mail: <a href="mailto:wxu02@stanford.edu">Weifeng Xu</a> <br><b>Postdoc Research Associate</b> <br> <br> Unavailable: <a href="mailto:">Daniel Saal</a> <br><b>Postdoc Research Associate</b> <br> <br> E-mail: <a href="mailto:wju@stanford.edu">William Ju</a> <br><b>Postdoc Research Associate</b> <br> <br> E-mail: <a href="mailto:rozer@stanford.edu">Rachel Ozer</a> <br><b>Postdoc Research Associate</b> <br> <br> E-mail: <a href="mailto:ssingla@stanford.edu">Sheela Singla</a> <br><b>Graduate Student</b> <br> <br> E-mail: <a href="mailto:jerron@stanford.edu">Jerron Fisher</a> <br><b>Research Technician</b> <br> <br> E-mail: <a href="mailto:regalado@stanford.edu">Maria Paz Regalado</a> <br><b>Postdoc Research Associate</b> <br> <br> E-mail: <a href="mailto:vgruver@stanford.edu">Vicki Gruver</a> <br><b>Lab Administrative Associate</b> <br> <br> E-mail: <a href="mailto:esaura@stanford.edu">Liz Saura</a> <br><b>Research Technician</b> <br> <br> E-mail: <a href="mailto:yuxiang@stanford.edu">Xiang Yu</a> <br><b>Postdoc Research Associate</b> <br> <br> E-mail: <a href="mailto:desseiro@stanford.edu">Karl Deisseroth</a> <br><b>Postdoc Research Associate</b> <br> <br> E-mail: <a href="mailto:hmarie@stanford.edu">Hélène Marie</a> <br><b>Postdoc Research Associate</b> <br> <a href="#ln_publi" target="_self">LIST OF PUBLICATIONS</a> <br> <br> E-mail: <a href="mailto:mpak@stanford.edu">Melissa Pak</a> <br><b>Research technician</b> <br> <br> E-mail: <a href="mailto:oliver.shluter@stanford.edu">Oliver Schlüter</a> <br><b>Postdoc Research Associate</b> <br> <br> <A NAME=contact> <br> <A HREF="#home" TARGET="_self">Home</A> | <A HREF="#people" TARGET="_self">People</A> | <A HREF="#contact" TARGET="_self">Contact</A> | <A HREF="#rob_publi" TARGET="_self">Rob Malenka`s Publications</A> | <A HREF="#Login" TARGET="_self">Login</A> <H2>Contact</H2> <b>Nancy Pritzker Laboratory</b> <br>Department of Psychiatry and Behavioral Sciences<br> <br><b>Stanford University Medical Center</b> <br> <br> Address:<br> 1201 Welch Road, Room P107<br> Palo Alto, CA 94304-5485 <br> <br> Tel.: (650) 498-7760<br> Fax: (650) 498-7761 <br> <P ALIGN=JUSTIFY> Please do not hesitate to contact our administrative associate, <a href="mailto:vgruver@stanford.edu" target="_blank">Vicki</a>, for further information.</P> <br> <br> <A NAME=#rob_publi> <br> <A HREF="#home" TARGET="_self">Home</A> | <A HREF="#people" TARGET="_self">People</A> | <A HREF="#contact" TARGET="_self">Contact</A> | <A HREF="#rob_publi" TARGET="_self">Rob Malenka`s Publications</A> | <A HREF="#Login" TARGET="_self">Login</A> <H2><b>Rob Malenka`s Publications</b><br><i>(1995-present; selected)</i></H2> <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed" target="_blank" border=0 CLASS="publink">Pubmeb website</a> <UL TYPE="square"> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7753197&dopt=Abstract" target="_blank">Crair, M.C. and Malenka, R.C.</a><br>A critical period for long-term potentiation at thalamocortical synapses.<br><b>Nature</b> 375: 325-328, 1995.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7777057&dopt=Abstract" target="_blank">Rosahl, T.W., Spillane, D., Missler, M., Herz, J., Selig, D., Wolff, J.R., Hammer, R.E., Malenka, R.C., and Sudhof, T.C.</a><br>Essential functions of synapsins I and II in synaptic vesicle regulation.<br><b>Nature</b> 375: 488-493, 1995.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7544143&dopt=Abstract" target="_blank">Selig, D.K., Hjelmstad, G.O., Herron, C., Nicoll, R.A. and Malenka, R.C.</a><br>Independent mechanisms for long-term depression of AMPA and NMDA responses.<br><b>Neuron</b> 15: 417-426, 1995.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7646894&dopt=Abstract" target="_blank">Isaac, J.T.R., Nicoll, R.A. and Malenka, R.C.</a><br>Evidence for silent synapses: Implications for the expression of LTP.<br><b>Neuron</b> 15: 427-434, 1995.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7479960&dopt=Abstract" target="_blank">Lledo, P.M., Hjelmstad, G., Mukherji, S., Soderling, T.R., Malenka, R.C., and Nicoll, R.A.</a><br>CaM-kinase II and LTP enhance synaptic transmission by the same mechanism.<br><b>Proc. Natl. Acad. Sci. USA</b> 92: 11175-11179, 1995.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7675078&dopt=Abstract" target="_blank">Nicoll, R.A. and Malenka, R.C.</a><br>Contrasting properties of two forms of LTP in the hippocampus.<br><b>Nature</b> 377: 115-118, 1995.<br></P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8774428&dopt=Abstract" target="_blank">Nicola, S.M., Kombian, S.B. and Malenka R.C.</a><br>Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors.<br><b>J. Neurosci.</b> 16: 1591-1604, 1996.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8638114&dopt=Abstract" target="_blank">Oliet, S.H.R., Malenka, R.C., and Nicoll, R.A.</a><br>Bidirectional control of quantal size by synaptic activity in the hippocampus.<br><b>Science</b> 271: 1294-1297, 1996.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8917586&dopt=Abstract" target="_blank">Salin, P.A., Scanziani, M., Malenka, R.C. and Nicoll R.A.</a><br>Distinct short-term plasticity at two excitatory synapses in the hippocampus.<br><b>Proc. Natl. Acad. Sci. USA</b> 93: 13304-13309, 1996.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8602244&dopt=Abstract" target="_blank">Scanziani, M., Malenka, R.C. and Nicoll, R.A.</a><br>Role of intercellular interactions in heterosynaptic long-term depression<br><b>Nature</b> 380: 446-450, 1996.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8607997&dopt=Abstract" target="_blank">Salin, P.A., Malenka, R.C., and Nicoll, R.A.</a><br>Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses.<br><b>Neuron</b> 16: 797-803, 1996.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8608000&dopt=Abstract" target="_blank">Cummings, J.A., Mulkey, R.M., Nicoll, R.A., and Malenka, R.C.</a><br>Calcium signaling requirements for long-term depression in the hippocampus.<br><b>Neuron</b> 16: 825-833, 1996.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8663991&dopt=Abstract" target="_blank">Tong, G., Malenka, R.C., and Nicoll, R.A.</a><br>Long-term potentiation in cultures of single hippocampal granule cells: a presynaptic form of plasiticy.<br><b>Neuron</b> 16: 1147-1157, 1996.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8710936&dopt=Abstract" target="_blank">Isaac, J.T.R., Hjelmstad, G.O., Nicoll, R.A., and Malenka, R.C.</a><br>Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells.<br><b>Proc. Natl. Acad. Sci. USA</b> 93: 8710-8715, 1996.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9024660&dopt=Abstract" target="_blank">Scanziani, M., Salin, P., Malenka, R.C. and Nicoll, R.A.</a><br>Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors.<br><b>Nature</b> 385: 630-634, 1997.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9052797&dopt=Abstract" target="_blank">Isaac, J.T.R., Crair, M.C., Nicoll, R.A. and Malenka, R.C.</a><br>Silent synapses during development of thalamocortical synapses.<br><b>Neuron</b> 18: 269-280, 1997.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9217159&dopt=Abstract" target="_blank">Castillo, P., Malenka, R.C. and Nicoll, R.A.</a><br>Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons.<br><b>Nature</b> 388: 182-186, 1997.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9208864&dopt=Abstract" target="_blank">Oliet, S.H.R., Malenka, R.C. and Nicoll, R.A.</a><br>Two distinct forms of long-term depression coexist in CA1 hippocampal pryamidal cells.<br><b>Neuron</b> 18: 969-982, 1997.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9221769&dopt=Abstract" target="_blank">Nicola, S.M. and Malenka, R.C.</a><br>Dopamine depresses excitatory and inhibitory synaptic transmission via distinct mechanisms in the nucleus accumbens.<br><b>J. Neurosci.</b> 17: 5697-5710, 1997.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9252190&dopt=Abstract" target="_blank">Castillo, P.E., Janz, R., Sudhof, T.C., Tzounopoulos, T., Malenka, R.C. and Nicoll, R.A.</a><br>The synaptic vesicle protein Rab3A is essential for mossy fibre long-term potentiation in the hippocampus.<br><b>Nature</b> 388: 590-593, 1997.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9331358&dopt=Abstract" target="_blank">Luscher, C., Jan, L.Y., Stoffel, M., Malenka, R.C. and Nicoll, R.A.</a><br>G-protein inwardly rectifying K+ channels (GIRKs) mediate postsynaptic, but not presynaptic transmitter actions in hippocampal neurons.<br><b>Neuron</b> 19: 687-695, 1997.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9427253&dopt=Abstract" target="_blank">Hjelmstad, G.O., Nicoll, R.A. and Malenka, R.C.</a><br>Synaptic refractory period provides a measure of probability of release in the hippocampus.<br><b>Neuron</b> 19: 1309-1318, 1997.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9430593&dopt=Abstract" target="_blank">Lledo, P.-M., Zhang, S., Sudhof, T.C., Malenka, R.C. and Nicoll. R.A.</a><br>Postsynaptic membrane fusion and long-term potentiation.<br><b>Science</b> 279: 399-403, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9618545&dopt=Abstract" target="_blank">Lissin, D.V., Gomperts, S.N., Carroll, R., Christine, C.W., Kallman, D., Kitamura, M., Hardy, S., Nicoll, R.A., Malenka, R.C. and Von Zastrow, M.</a><br>Activity differentially regulates the surface expression of synaptic AMPA and NMDA receptors<br><b>Proc. Natl. Acad. Sci. USA</b> 95: 7097-7102, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9728924&dopt=Abstract" target="_blank">Luscher C., Malenka, R. C., and Nicoll, R. A.</a><br>Monitoring glutamate release during LTP with glial transporter currents.<br><b>Neuron</b> 21:435-441, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9728916&dopt=Abstract" target="_blank">Feldman, D.E., Nicoll, R.A., Malenka, R.C., Isaac J. T. R.</a><br>Long-term depression at thalamocortical synapses in developing rat somatosensory cortex.<br><b>Neuron</b> 21: 347-357, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10196545&dopt=Abstract" target="_blank">Frerking, M., Malenka, R. C., and Nicoll, R. A.</a><br>Synaptic activation of kainate receptors on hippocampal interneurons.<br><b>Nature Neuroscience</b> 1: 479-486, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9808469&dopt=Abstract" target="_blank">Tzounopoulos, T., Janz, R., Sudhof, T. C., Nicoll, R. A., and Malenka, R. C.</a><br>A role for cAMP in long-term depression at hippocampal mossy fiber synapses.<br><b>Neuron</b> 21: 837-845, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9883736&dopt=Abstract" target="_blank">Gomperts, S.N., Rao, A., Craig, A.M., Malenka, R.C. and Nicoll, R.A.</a><br>Postsynaptically silent synapses in single neuron cultures.<br><b>Neuron</b> 21: 1443-1451, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9535965&dopt=Abstract" target="_blank">Hsia, A.Y., Malenka, R.C. and Nicoll, R.A.</a><br>Development of excitatory circuitry in the hippocampus<br><b>J. Neurophysiol</b> 79: 2013-2024, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9539807&dopt=Abstract" target="_blank">Petersen, C.C.H., Malenka, R.C., Nicoll, R.A. and Hopfield, J.J.</a><br>All-or-none potentiation at CA3-CA1 synapses.<br><b>Proc. Natl. Acad. Sci. USA</b> 95: 4732-4737, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9819284&dopt=Abstract" target="_blank">Carroll, R.C, Nicoll, R.A. and Malenka, R.C.</a><br>Effects of PKA and PKC on miniature excitatory postsynaptic currents in CA1 pyramidal cells.<br><b>J. Neurophysiol</b> 80: 2797-2800, 1998.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9952404&dopt=Abstract" target="_blank">Lissin, D.V., Carroll, R.C., Nicoll, R.A., Malenka, R.C. and Von Zastrow, M.</a><br>Rapid, activation-induced redistribution of glutamate receptors in cultured hippocampal neurons.<br><b>J. Neurosci</b> 19: 1263-1272, 1999.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10321250&dopt=Abstract" target="_blank">Carroll, R.C., Lissin, D.V., Von Zastrow, M., Nicoll, R.A. and Malenka, R.C.</a><br>Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures.<br><b>Nature Neuroscience</b> 2: 454-460, 1999.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9952401&dopt=Abstract" target="_blank">Selig, D.K., Nicoll, R.A. and Malenka, R.C.</a><br>Hippocampal long-term potentiation preserves the fidelity of postsynaptic responses to presynaptic bursts.<br><b>J. Neurosci</b> 19: 1236-1246, 1999.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10489359&dopt=Abstract" target="_blank">Malenka, R.C. and Nicoll, R.A.</a><br>Long-term potentiation-A decade of progress?<br><b>Science</b> 285: 1870-1874, 1999.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10234004&dopt=Abstract" target="_blank">Bonci, A. and Malenka, R.C.</a><br>Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area.<br><b>J. Neurosci</b> 19: 3723-3730, 1999.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10595516&dopt=Abstract" target="_blank">L�scher, C., Xia, H., Beattie, E.C., Caroll, R.C., von Zastrow, M., Malenka, R.C. and Nicoll, R.A.</a><br>Role of AMPA receptor cycling in synaptic transmission and plasticity.<br><b>Neuron</b> 24: 649-658, 1999.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10570207&dopt=Abstract" target="_blank">Carroll, R., Beattie, E., Xia, H., L�scher, C., Altschuler, Y., Nicoll, R., Malenka, R., and von Zastrow, M.</a><br>Dynamin-dependent endocytosis of ionotropic glutamate receptors.<br><b>Proc. Natl. Acad. Sci. USA</b> 96: 14112-14117, 1999.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10407024&dopt=Abstract" target="_blank">Schlueter,O.M., Schnell, E., Verhage, M., Tzonopoulos, T., Nicoll, R.A., Janz, R., Malenka, R.C., Geppert, M. and Sudhof, T.</a><br>Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release.<br><b>J. Neurosci</b> 19: 5834-5846, 1999.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10704498&dopt=Abstract" target="_blank">Gomperts, S., Carroll, R., Malenka., R.C., and Nicoll, R.</a><br>Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses.<br><b>J. Neurosci</b> 20: 2229-2237, 2000.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10845063&dopt=Abstract" target="_blank">Nicola, S., Surmeier, J., and Malenka, R.C.</a><br>Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens.<br><b>Annu. Rev. Neurosci</b> 23: 185-215, 2000.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10816309&dopt=Abstract" target="_blank">Luscher, C., Nicoll, R.A., Malenka, R.C., and Muller, D.</a><br>Synaptic plasticity and dynamic modulation of the postsynaptic membrane.<br><b>Nature Neurosci</b> 3: 545-550, 2000.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10908594&dopt=Abstract" target="_blank">Thomas, M.T., Malenka, R.C., and Bonci, A.</a><br>Modulation of long-term depression by dopamine in the mesolimbic system.<br><b>J. Neurosci</b> 20: 5581-5586, 2000.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11100150&dopt=Abstract" target="_blank">Beattie, E.C., Carroll, R.C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., and Malenka, R.C.</a><br>Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD.<br><b>Nature Neurosci</b> 3: 1291-1300, 2000.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11224537&dopt=Abstract" target="_blank">Barth, A. L. and Malenka, R.C.</a><br>NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses.<br><b>Nature Neurosci</b> 4: 235-236, 2001.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11331915&dopt=Abstract" target="_blank">Carroll, R.C., Beattie, E.C., Von Zastrow, M. and Malenka, R.C.</a><br>Role of AMPA receptor endocytosis in synaptic plasticity.<br><b>Nature Rev. Neurosci</b> 2: 315-324, 2001.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11385572&dopt=Abstract" target="_blank">Ungless, M., Whistler, J., Malenka, R.C., and Bonci, A.</a><br>Single <i>in vivo</i> cocaine exposure induces long-term potentiation in midbrain dopamine neurons.<br><b>Nature</b> 411: 583-587, 2001.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11584307&dopt=Abstract" target="_blank">Hyman, S.E. and Malenka, R.C.</a><br>Addiction and the brain: the neurobiology of compulsion and its persistence.<br><b>Nature Rev. Neurosci</b> 2: 695-703, 2001.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11694884&dopt=Abstract" target="_blank">Thomas, M.J., Beurrier, C., Bonci, A. and Malenka, R.C.</a><br>Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine.<br><b>Nature Neurosci</b> 4: 1217-1223, 2001.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11754843&dopt=Abstract" target="_blank">Morishita, W., Connor, J.H., Xia, H.,Quinlan, E.M., Shenolikar, S. and Malenka R.C.</a><br>Regulation of synaptic strength by protein phosphatase 1.<br><b>Neuron</b> 32: 1133-1148, 2001.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11797009&dopt=Abstract" target="_blank">Schoch, S., Castillo, P.E., Jo, T., Mukherjee, K., Geppert, M., Wan, Y., Schmitz, F., Malenka, R.C. and Sudhof, T.C.</a><br>Riml<i>alpha</i> forms a protein scaffold for regulating neurotransmitter release at the active zone.<br><b>Nature</b> 415: 321-326, 2002. </P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11797010&dopt=Abstract" target="_blank">Castillo, P.E., Schoch, S., Schmitz, F., Sudhof, T.C. and Malenka, R.C.</a><br>Riml<i>alpha</i> is required for presynaptic long-term potentiation.<br><b>Nature</b> 415: 327-330, 2002.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11910117&dopt=Abstract" target="_blank">Beattie, E., Stellwagen, D., Morishita, W., Bresnahan, J., Ha, B.K., Von Zastrow, M, Beattie, M.S. and Malenka, R.C.</a><br>Control of synaptic strength by glial TNF<i>alpha</i>.<br><b>Science</b> 295: 2282-2285, 2002.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12011465&dopt=Abstract" target="_blank">Braithwaite, S.P., Xia, H., and Malenka, R.C.</a><br>Differential roles for NSF and GRIP/ABP in AMPA receptor cycling.<br><b>Proc. Natl. Acad. Sci. USA</b> 99: 7096-7101, 2002.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12052905&dopt=Abstract" target="_blank">Malinow, R. and Malenka R.C.</a><br>AMPA receptor trafficking and synaptic plasticity.<br><b>Annu. Rev. Neurosci</b> 25: 103-126, 2002.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12122043&dopt=Abstract" target="_blank">Beurrier, C. and Malenka, R.C.</a><br>Enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine.<br><b>J. Neurosci</b> 22: 5817-5822, 2002.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12367503&dopt=Abstract" target="_blank">Malenka, R.C.</a><br>NIH workshop report: taming the brain's complexity.<br><b>Neuron</b> 36: 29-30, 2002.</P></LI> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12368290&dopt=Abstract" target="_blank">Xia, H., Von Zastrow, M. and Malenka R.C.</a><br>A novel anterograde trafficking signal present in the N terminal extracellular domain of ionotropic glutamate receptors.<br><b>J. Biol. Chem.</b> (in press)</P></LI> </UL> <b>Books</b> <UL TYPE="square"> <LI><P ALIGN=JUSTIFY>Nestler, E., Hyman, S., and Malenka, R.C.<br><u>Molecular Neuropharmacology: A Foundation for Clinical Neuroscience</u>, McGraw-Hill, New York (2001).</P></LI> </UL> <br> <br> <A NAME=login> <br> <A HREF="#home" TARGET="_self">Home</A> | <A HREF="#people" TARGET="_self">People</A> | <A HREF="#contact" TARGET="_self">Contact</A> | <A HREF="#rob_publi" TARGET="_self">Rob Malenka`s Publications</A> | <A HREF="#Login" TARGET="_self">Login</A> <H2>Login</H2> This function is not currently available from that page. <br> <br> Please allow your browser to open with frames. <br> <br> <br> <br> <a href="http://malenkalab.stanford.edu" target="_self">http://malenkalab.stanford.edu</a> <br> <br> <a href="mailto:houdevincent@hotmail.com?subject=Malenka Lab Webdesign" target="_blank">Webmaster<br>� 2002</a> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <br> <A NAME=ln_publi> <br> <A HREF="#home" TARGET="_self">Home</A> | <A HREF="#people" TARGET="_self">People</A> | <A HREF="#contact" TARGET="_self">Contact</A> | <A HREF="#rob_publi" TARGET="_self">Rob Malenka`s Publications</A> | <A HREF="#Login" TARGET="_self">Login</A> <H2><b>Hélène Marie`s Publications</b><br><i>(1999-present)</i></H2> <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed" target="_blank" border=0 CLASS="publink">Pubmeb website</a>  <UL TYPE="square"> <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12417594&dopt=Abstract">Marie H, Pratt SJ, Betson M, Epple H, Kittler J, Meek L, Moss S, Attwell D, Longmore GD, Braga VM.</a><BR> The LIM protein ajuba is recruited to cadherin-dependent cell junctions through an association with alpha -catenin.<BR> <b>J Biol Chem.</b> 2002 Nov 1 [epub ahead of print]<BR>PMID: 12417594 [PubMed - as supplied by publisher] </P></LI>  <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11860269&dopt=Abstract">Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D.</a><BR> The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba.<BR> <b>Mol Cell Neurosci.</b> 2002 Feb;19(2):152-64.<BR> PMID: 11860269 [PubMed - indexed for MEDLINE] </P></LI>  <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11849297&dopt=Abstract">Hamann M, Rossi DJ, Marie H, Attwell D.</a><BR> Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia.<BR> <b>Eur J Neurosci.</b> 2002 Jan;15(2):308-14.<BR> PMID: 11849297 [PubMed - indexed for MEDLINE] </P></LI>  <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11606645&dopt=Abstract">Parkinson DB, Dong Z, Bunting H, Whitfield J, Meier C, Marie H, Mirsky R, Jessen KR.</a><BR> Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation.<BR> <b>J Neurosci.</b> 2001 Nov 1;21(21):8572-85.<BR> PMID: 11606645 [PubMed - indexed for MEDLINE] </P></LI>  <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11316002&dopt=Abstract">Gray C, Marie H, Arora M, Tanaka K, Boyde A, Jones S, Attwell D.</a><BR> Glutamate does not play a major role in controlling bone growth.<BR> <b>J Bone Miner Res.</b> 2001 Apr;16(4):742-9.<BR> PMID: 11316002 [PubMed - indexed for MEDLINE] </P></LI>  <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11029037&dopt=Abstract">Kanungo J, Pratt SJ, Marie H, Longmore GD.</a><BR> Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions.<BR> <b>Mol Biol Cell.</b> 2000 Oct;11(10):3299-313.<BR> PMID: 11029037 [PubMed - indexed for MEDLINE] </P></LI>  <LI><P ALIGN=JUSTIFY><a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10523408&dopt=Abstract">Marie H, Attwell D.</a><BR> C-terminal interactions modulate the affinity of GLAST glutamate transporters in salamander retinal glial cells.<BR> <b>J Physiol.</b> 1999 Oct 15;520 Pt 2:393-7.<BR> PMID: 10523408 [PubMed - indexed for MEDLINE] </P></LI>  </UL> </BODY>